Main Databases Used in Haz-Map (# of Records)

ACGIH Documentation of TLVs and BEIs (700+)

Haz-Map includes all chemicals in the American Conference of Governmental Industrial Hygienists (ACGIH) database. ACGIH fields in Haz-Map are Cancer Designation, Skin Designation, Biological Exposure Index (BEI), TLV, STEL, and Ceiling. The last three are recommended occupational exposure levels (workplace air levels not to be exceeded). ACGIH profiles are updated regularly and include summaries of occupational epidemiology and animal toxicology for each substance covered. The “2010 Supplement to the 7th Edition” has 21 profiles of newly adopted or updated substances (15 for TLVs and 6 for BEIs). The 2011 and 2012 supplements were purchased and reviewed: 9 for TLVs and 1 for BEIs (2011 profiles) and 8 for TLVs and 2 for BEIs (2012 profiles). Review of the 2013 TLVs and BEIs and 2013 Supplement to the 7th Edition was completed and will be published later this year.

NIOSH Pocket Guide to Chemical Hazards (700+) and IDLH (300+)

Haz-Map includes all chemicals in the NIOSH Pocket Guide. There are 322 chemicals in Haz-Map with IDLHs (warning air levels for Immediately Dangerous for Life and Health). The NIOSH Pocket Guide is based on research from over 40 years ago, and the disease information does not reflect the current state of scientific knowledge. There are no references in the Pocket Guide. The lists of symptoms and target organs have not changed when comparing the 1997 and 2007 editions.  The introductions in those two editions mention some revisions to parts of the Pocket Guide but not to the symptoms or target organs. The Pocket Guide does not distinguish between symptoms of acute or chronic diseases; it does not distinguish between adverse effects caused by animal experiments, poisoning by ingestion, or occupational exposure.

NLM ChemIDplus (388,000+) and HSDB (5000+)

ChemIDplus contains over 380,000 records and over 295,000 chemical structures with links to other chemical databases on the web.  Hazardous Substances Data Bank (HSDB) contains over 5,000 profiles on toxic chemicals, updated by specialists at the US National Library of Medicine and peer reviewed by the Scientific Review Panel. Haz-Map includes all HSDB chemicals that are important in terms of occupational exposure.

ATSDR ToxProfiles (300+) and Case Studies (30+)

"The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties." There are about 300 chemical toxicological profiles. About 30 "Case Studies" profiles have been published.

EPA CAMEO (6000+)

CAMEO Chemicals is a database of over 6,000 hazardous materials commonly transported, used, or stored in the United States; it has information about fire and explosive hazards and health effects developed by EPA and NOAA to assist emergency responders. Approximately 2700 Haz-Map chemicals include the "Reactive Groups" categories shown in CAMEO. These "Reactive Groups" in CAMEO help to classify chemicals into one of 12 main categories and one of 200+ subcategories in Haz-Map. A list of subcategories, as of March 2011, is here.

EXTOXNET: The EXtension TOXicology NETwork (183)

EXTOXNET is a cooperative effort of University of California-Davis, Oregon State University, Michigan State University, Cornell University, and the University of Idaho. Primary files are maintained and archived at Oregon State University. The 183 pesticides covered by EXTOXNET are included in Haz-Map.

Emergency Response Guidebook 2012 (1500+)

There are about 2500 chemicals in Haz-Map with ERG 2012 information: links to the specific Guides and designations of "Explosive Polymerization," "Dangerous When Wet," and "TIH" (Toxic Inhalation Hazard). The Emergency Response Guidebook was developed jointly by the US Department of Transportation, Transport Canada, and the Secretariat of Communications and Transportation of Mexico, and Centro de Informacion Quimica para Emergencias of Argentina as an aid for firefighters, police, and other emergency responders to quickly identify hazardous materials and to protect themselves and the general public at the time of chemical spills or releases. For each hazardous chemical, the first responder is referred to one of 62 Guides, e.g., Guide 125 (Gases - Corrosive) or Guide 127 (Flammable Liquids). ERG 2012 is used to help classify chemicals in Haz-Map. It is also used to help define "Pneumonitis, toxic."

IPCS INCHEM

A joint project of the International Programme on Chemical Safety (IPCS) and the Canadian Centre for Occupational Safety (CCOHS), this Internet portal provides access to profiles for thousands of chemicals. Important databases accessible through INCHEM include International Chemical Safety Cards (ICSC), International Agency for Research on Cancer (IARC) Monographs, Joint Expert Committee on Food Additives (JECFA) Monographs, Joint Meeting on Pesticide Residues (JMPR) Monographs, and Screening Information Data Set (SIDS) for High Production Volume Chemicals.

EPA REDs

These are the REDs (Reregistration Eligibility Decisions) for dozens of individual pesticide active ingredients. RED documents contain the results of EPA's regulatory reviews of pesticides initially registered before November 1, 1984.

Registry of Toxic Effects of Chemical Substances (RTECS)

RTECS is data from animal experiments extracted from the open scientific literature and includes primary irritation, mutagenic effects, reproductive effects, tumorigenic effects, acute toxicity, and other multiple dose toxicity. RTECS provides values for LD50 and LC50 as well as route of administration and species studied. 

ExPub

Chemical hazard information for EH&S Professionals, ExPub has millions of documents from over 100 sources. Document sites include: EPA OHM/TADS (Oil and Hazardous Materials Technical Assistance Data System, EPA ChAMP (Chemical Assessment and Management Program), REPROTOX, RTECS (Registry of Toxic Effects of Chemical Substances), FDA (US Food and Drug Administration), EFSA (European Food Safety Authority), and OECD SIDS (Organization for Economic Co-operation and Development Screening Information Data Set). Subscription is required for ExPub. 

 

SEM (15,000+)

The SEM (Site Exposure Matrix) database contains over 15,000 chemicals/trade names based on records of chemicals used at U.S. federal facilities for nuclear weapons research and development during the Cold War. Many of these chemical are rarely used, and information is scarce. Whenever possible, these chemicals are compared to more well-known chemicals with similar structures. The SEM database also includes many common chemicals of biological origin that were not originally in Haz-Map. It was decided to add rather than ignore these biological agents (monosaccharides, amino acids, proteins, vitamins, etc.) because they demonstrate that all chemicals are toxic at sufficient dose, and their structures can be compared to other chemicals already in the database. Haz-Map does not include drugs unless they are involved in important occupational exposures. Generally, it does not include alloys or commercial mixtures.

For other books and databases used to make Haz-Map, see the Bibliography page.

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