Dichloroaniline, mixed isomers

Synonyms

Ar,ar-dichlorobenzenamine; [ChemIDplus] UN1590

Category

Amines, Aromatic

Description

Fine, light-tan crystals (3,4-dicloroaniline)

Sources/Uses

3,4-Dichloroaniline is used as an intermediate in the production of dyes and herbicides (diuron and propanil); [HSDB]

Comments

Listed in a table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] Contaminants of 3,4-dichloroaniline can induce chloracne; [Rosenstock, p. 714] Some workers exposed to 3,4-dichloroaniline during the production of diuron, a herbicide, developed chloracne and elevation of liver function test results. [HSDB]

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Yes

must be preheated

MetHgb is primary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Chloracne

Diseases

Occupational diseases associated with exposure to this agent:

• Chloracne
• Methemoglobinemia, acute