2,4-Xylidine

Synonyms

1-Amino-2,4-dimethylbenzene; 2,4-Dimethylaniline; 2,4-Dimethylbenzenamine; 2,4-Dimethylphenylamine; 2-Methyl-p-toluidine; 4-Amino-1,3-dimethylbenzene; 4-Amino-1,3-xylene; 4-Amino-3-methyltoluene; 4-Methyl-o-toluidine; Aniline, 2,4-dimethyl-; Benzenamine, 2,4-dimethyl-; m-4-Xylidine; m-Xylidine; meta-Xylidine; [ChemIDplus] UN1711

Category

Amines, Aromatic

Description

Clear, pale yellow liquid; Turns reddish to brown when exposed to air; [ICSC] Dark brown liquid; [CAMEO] Colorless to tan liquid; [HSDB] Yellow liquid; [Alfa Aesar MSDS]

Sources/Uses

Used to make pharmaceuticals, pesticides, dyes, and photographic chemicals; [HSDB] Also used to make wood preservatives, wetting agents for textiles, frothing agents for ore dressing, metal complexes, and special lacquers; [EPA PPRTV]

Comments

An eye and mild skin irritant; Can be absorbed through skin; Inhalation of high concentrations can cause methemoglobinemia and lowering of consciousness; Repeated or chronic exposure may have effects on the blood (anemia), liver, and kidney; High dose animal studies have produced liver necrosis, inhibition of DNA synthesis in the testes, and evidence of mutagenicity; [ICSC] A severe eye irritant in rabbits, with corneal opacity and conjunctival irritation persisting in some animals until study termination (21 days); Produced skin sensitization in 50% of guinea pigs using a modified Buehler method; [EPA TSCATS] An irritant; Toxic by ingestion, inhalation, and skin absorption; May have cumulative adverse effects to organs; [Alfa Aesar MSDS] See "Xylidine, mixed isomers."

Biomedical References

0.133 mm Hg

LC50 (rat) = 1,530 mg/m3/4hr

Explanatory Notes

LC50 (mouse) = 149 ppm/7hr; The Guide in the Emergency Response Guidebook is for "Xylidines."

must be preheated

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Not classifiable

Other Information

No other related information on this agent was found.