2,4-Xylidine

Agent Name
2,4-Xylidine
CAS Number
95-68-1
Formula
C8-H11-N
Major Category
Nitrogen Compounds
2,4-Xylidine formula graphical representation
Synonyms
1-Amino-2,4-dimethylbenzene; 2,4-Dimethylaniline; 2,4-Dimethylbenzenamine; 2,4-Dimethylphenylamine; 2-Methyl-p-toluidine; 4-Amino-1,3-dimethylbenzene; 4-Amino-1,3-xylene; 4-Amino-3-methyltoluene; 4-Methyl-o-toluidine; Aniline, 2,4-dimethyl-; Benzenamine, 2,4-dimethyl-; m-4-Xylidine; m-Xylidine; meta-Xylidine; [ChemIDplus] UN1711
Category
Amines, Aromatic
Description
Clear, pale yellow liquid; Turns reddish to brown when exposed to air; [ICSC] Dark brown liquid; [CAMEO] Colorless to tan liquid; [HSDB] Yellow liquid; [Alfa Aesar MSDS]
Sources/Uses
Used to make pharmaceuticals, pesticides, dyes, and photographic chemicals; [HSDB] Also used to make wood preservatives, wetting agents for textiles, frothing agents for ore dressing, metal complexes, and special lacquers; [EPA PPRTV]
Comments
An eye and mild skin irritant; Can be absorbed through skin; Inhalation of high concentrations can cause methemoglobinemia and lowering of consciousness; Repeated or chronic exposure may have effects on the blood (anemia), liver, and kidney; High dose animal studies have produced liver necrosis, inhibition of DNA synthesis in the testes, and evidence of mutagenicity; [ICSC] A severe eye irritant in rabbits, with corneal opacity and conjunctival irritation persisting in some animals until study termination (21 days); Produced skin sensitization in 50% of guinea pigs using a modified Buehler method; [EPA TSCATS] An irritant; Toxic by ingestion, inhalation, and skin absorption; May have cumulative adverse effects to organs; [Alfa Aesar MSDS] See "Xylidine, mixed isomers."
Biomedical References

Exposure Assessment

Vapor Pressure
0.133 mm Hg
Lethal Concentration
LC50 (rat) = 1,530 mg/m3/4hr
Explanatory Notes
LC50 (mouse) = 149 ppm/7hr; The Guide in the Emergency Response Guidebook is for "Xylidines."
NFPA
must be preheated

Adverse Effects

Methemoglobinemia
MetHgb is secondary toxic effect
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
IARC Carcinogen
Not classifiable

Diseases, Processes, and Activities Linked to This Agent

Other Information
No other related information on this agent was found.