1,1,1,2-Tetrachloroethane

Synonyms

Ethane, 1,1,1,2-tetrachloro-; 1,1,1,2-Tetrachlorethane; [ChemIDplus] (Chloromethyl) trichloromethane; Asym-tetrachloroethane; F130A; HCC 130A; TCA; [CAMEO] UN1702

Category

Chlorinated Aliphatics

Description

Yellowish-red liquid; [NIOSH] Yellow to red liquid; [ICSC] Clear colorless liquid; [NTP]

Sources/Uses

Used to make other organic chemicals; [ATSDR ToxFAQs] Used as a solvent; [HSDB]

Comments

Target organs are skin, eyes, CNS, and liver. [NIOSH] A skin and eye irritant; May cause CNS effects; [ICSC] An irritant and lachrymator; May cause CNS depression, albuminuria, hematuria, hepatomegaly, jaundice, nephritis, polyneuritis, and skin and eye burns; No evidence of carcinogenicity in mice, equivocal evidence in male rats, and no evidence in female rats; [NTP] An irritant that may cause serious eye injury; Harmful by ingestion and inhalation; Targets the nerves, liver, and kidney; [Sigma-Aldrich MSDS] See "1,1,2,2-Tetrachloroethane."

Commercial production has ceased in the U.S. It is still used as a chemical intermediate to synthesize organic chemicals. [ATSDR ToxFAQs]

Biomedical References

12 mm Hg

LC50 (rat) = 2,100 ppm/4hr

Explanatory Notes

VP from HSDB;

Yes

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Possible (2b)

Diseases

Occupational diseases associated with exposure to this agent:

• Encephalopathy, chronic solvent
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Leather Tanning and Processing
• Metal Degreasing
• Painting (Solvents)