Methylisothiazolinone
Agent Name
Methylisothiazolinone
CAS Number
2682-20-4
Formula
C4-H5-N-O-S
Major Category
Other Uses
Synonyms
2-Methyl-3(2H)-isothiazolone; 2-Methyl-4-isothiazolin-3-one; 2-Methyl-2H-isothiazol-3-one; 2-Methyl-4-isothiazolin-3-one calcium chloride; 3(2H)-Isothiazolone, 2-methyl-; MI; [ChemIDplus] 2-Methyl-2,3-dihydroisothiazol-3-one; [ACGIH Guide to Occupational Exposure Values, 2002] MIT; Neolone 950; [Merck Index] 2-Methylisothiazol-3(2H)-one; [EC: SCCS - Opinion] UN3261
Category
Biocides/Disinfectants
Description
Colorless solid; [Merck Index] Dark yellow powder with lumps; [Sigma-Aldrich MSDS]
Sources/Uses
Used as a biocide and preservative in cosmetics, paints, and glues; it is present in Kathon KG, MCI/MI, and Euxyl K100; [Kanerva, p. 1815] Used as an antimicrobial in cosmetics, hygiene products, paints, emulsions, cutting oils, paper coatings, and water storage and cooling units; [Merck Index] Used as a biocide in textile production; [Danish Ministry of the Environment] Used as a preservative in pesticide products; [EPA - Inert Reassessments] Used as a biocide in pulp/paper mills, industrial process and cooling water systems, oil field operations, and air cleaner systems, and as a preservative in adhesives, coatings, fuels, metalworking fluids, resin emulsions, paints, and wood products; [Reference #1]
Comments
Allergic contact dermatitis reported in workers using products containing this preservative; [Kanerva, p. 1815] Danger of skin sensitization; [MAK] Cosmetic preservative that is a recognized contact allergen in consumers; [EC: SCCS - Opinion] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; May cause skin sensitization; Harmful by ingestion; Toxic by inhalation; [Sigma-Aldrich MSDS] See "ISOTHIAZOLINONES."
Reference Link #1
Biomedical References
Exposure Assessment
MAK
0.2 mg/m3, inhalable fraction
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Corrosive solid, acidic, organic, n.o.s." MAK value is for 3:1 mixture of 26172-55-4 and 2682-20-4;
Adverse Effects
Skin Sensitizer
Yes
Toxic Pneumonitis
Yes
Dermatotoxin
Skin burns
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent:
Processes
Industrial Processes with risk of exposure: