Methyl cellosolve acetate

Synonyms

2-Methoxy-ethyl acetaat [Dutch]; 2-Methoxyaethylacetat [German]; 2-Methoxyethanol, acetate; 2-Methoxyethyl acetate; 2-Methoxyethyle, acetate de [French]; 2-Methoxyethylester kyseliny octove [Czech]; 2-Methyoxyethylacetate; 2-Metossietilacetato [Italian];Acetate de l'ether monomethylique de l'ethylene-glycol; [French]; Acetate de methyle glycol [French]; Acetato di metil cellosolve [Italian]; Acetic acid 2-methoxyethyl ester; Acetyl methyl cellosolve; Aethylenglykolmethylaetheracetat [German]; EGMEA; Ethanol, 2-methoxy-, acetate; Ethylene glycol acetate monomethyl ether; Ethylene glycol methyl ether acetate; Ethylene glycol monomethyl ether acetate; Ethylene glycol monomethyl ether monoacetate; Glycol monomethyl ether acetate; MeCsac; Methyl Cellosolve acetate; Methyl cellosolye acetaat [Dutch]; Methyl glycol acetate; Methyl glycol monoacetate; Methylcellosolveacetate; Methylcelosolvacetat [Czech]; Methylglycolacetate; Methylglykolacetat [German]; beta-Methoxyethyl acetate; [ChemIDplus] UN1189

Category

Glycol Ethers (E Series)

Description

Colorless liquid with a pleasant odor; [CAMEO]

Sources/Uses

Used as a solvent and in the production of photographic films and textile printing; [ACGIH]

Comments

After repeated 8-hour exposures to 200-1000 ppm, animals show evidence of kidney and bone marrow damage. [ACGIH] For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] Potential adverse effects include injury to the bone marrow, kidneys, and CNS (unconsciousness). May be a reproductive toxin and defat the skin; [ICSC] See "Glycol ethers."

The Semiconductor Industry Association recommends elimination of this solvent because of potential reproductive effects. [CHS, p. 43]

Biomedical References

2-Methoxyacetic acid in urine = 1 mg/g creatinine; end of shift at end of workweek; [ACGIH]

Yes

0.1 ppm

25 ppm

1 ppm, sum of concentrations of CAS 109-86-4 and its acetate in air

200 ppm

Excerpts from Documentation for IDLHs

Human data: It has been stated that methyl Cellosolve® acetate is slightly less toxic than methyl Cellosolve® [Gosselin et al. 1984].

7 mm Hg

0.33 ppm

Odor Threshold High

0.64 ppm

LCLo (rat) = 7,000 ppm/4 hr

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.33 ppm); Flash point = 111 deg F; VP from HSDB;

Reference Link #2

high ambient temp required

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Yes

Diseases

Occupational diseases associated with exposure to this agent:

• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Semiconductor Manufacturing
• Textiles (Printing, Dyeing, or Finishing)