Cyclohexanone
Agent Name
Cyclohexanone
CAS Number
108-94-1
Formula
C6-H10-O
Major Category
Solvents
Synonyms
Anon; Anone; Cyclohexanone; Cyclohexyl ketone; Hexanon; Hytrol O; Ketohexamethylene; Nadone; Pimelic ketone; Pimelin ketone; Sextone; [ChemIDplus] UN1915
Category
Ketones (<C12)
Description
Water-white to pale-yellow liquid with a peppermint- or acetone-like odor; [NIOSH]
Sources/Uses
Has many uses as an industrial solvent; used as a paint remover and in printing inks; [ACGIH]
Comments
Liquid causes first degree burns on short exposure; [CHRIS] Animals become stuporous in high-dose inhalation studies and develop liver necrosis after high-dose feeding studies. [ACGIH] [Sanmartin O, et al. Occupational contact dermatitis from cyclohexanone as a PVC adhesive. Contact Dermatitis. 1992 Sep;27(3):189-90. No abstract available. Abstract in NIOSHTIC #179644]
Reference Link #1
Biomedical References
Exposure Assessment
BEI
1,2-Cyclohexanediol (with hydrolysis) in urine: 80 mg/L (end of shift at end of workweek); Cyclohexanol (with hydrolysis) in urine: 8 mg/L (end of shift); See notations in ACGIH TLVs and BEIs.
Skin Designation (ACGIH)
Yes
TLV (ACGIH)
20 ppm
PEL (OSHA)
50 ppm
IDLH (NIOSH)
700 ppm
Excerpts from Documentation for IDLHs
It has been reported that exposure to 75 ppm for 3 to 5 minutes has resulted in pronounced irritation of the eyes, nose, and throat [Nelson et al. 1943].
Vapor Pressure
5 mm Hg
Odor Threshold Low
0.12 ppm
Odor Threshold High
100 ppm
RD50
756 ppm
Lethal Concentration
LC50 (rat) = 8,000 ppm/4 hr
Explanatory Notes
Detection odor threshold from AIHA (mean = 3.5 ppm); Flash point = 44 deg C; VP from HSDB;
Half Life
For 1,2-cyclohexanediol and 1,4-cyclohexanediol: 14-22 hours; [TDR, p. 434]
Reference Link #2
NFPA
high ambient temp required
Adverse Effects
Skin Sensitizer
Yes
Neurotoxin
Acute solvent syndrome
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Dermatotoxin
Skin burns
IARC Carcinogen
Not classifiable
ACGIH Carcinogen
Confirmed Animal
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent:
Processes
Industrial Processes with risk of exposure: