Piperidine

Synonyms

Hexahydropyridine; Azacyclohexane; Cyclopentimine; Cypentil; Hexazane; Pentamethyleneimine; Pentamethylenimine; Perhydropyridine; Piperidin [German]; Pyridine, hexahydro-; [ChemIDplus] UN2401

Category

Amines, Cyclic

Description

Colorless liquid with an amine odor; [HSDB]

Sources/Uses

Used as a chemical intermediate to produce drugs, wetting agents, and disinfectants; Also used as a rubber accelerator, a curing agent for epoxy resins, a flavoring agent, and an additive to oils and fuels; [HSDB]

Comments

Corrosive to skin; [Quick CPC] High inhalation exposure can cause pulmonary edema; [ICSC] Signs of toxicity in acute animal studies included respiratory distress, ataxia, weakness, paralysis, and convulsions; For humans, the irritation threshold is 26 ppm; workers can tolerate levels of 2-5 ppm for only a short period because of the odor; [AIHA] Oral doses of 30-60 mg/kg may cause weakness, vomiting, labored respiration, muscular paralysis, and asphyxia; [NTP] Safe when used as a flavoring agent in food; [JECFA] A skin sensitizer in guinea pigs; [EPA ChAMP] Causes impaired liver function tests in repeated dose inhalation studies of rats; [RTECS]

Biomedical References

32.1 mm Hg

LC50 (mice) = 6,000 mg/m3/2hr

Explanatory Notes

Odor threshold <2 ppm by volume; [AIHA] VP from HSDB;

may ignite at ambient temp

1 ppm

Yes

Other CNS neurotoxin

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Skin burns

Processes

Industrial Processes with risk of exposure:

• Plastic Composites Manufacturing