Isophorone

Synonyms

1,1,3-Trimethyl-3-cyclohexene-5-one; 2-Cyclohexen-1-one, 3,5,5-trimethyl-; 3,5,5-Trimethyl-2-cyclohexen-1-on [German, Dutch]; 3,5,5-Trimethyl-2-cyclohexen-1-one; 3,5,5-Trimethyl-2-cyclohexenone; 3,5,5-Trimetil-2-cicloesen-1-one [Italian]; Isoacetophorone; Isoforon; Isoforone [Italian]; Isooctopherone; Isophorone; Izoforon [Polish]; [ChemIDplus] UN8027

Category

Aliphatic Ketones, Other

Description

Colorless to white liquid with a peppermint-like odor; [NIOSH]

Sources/Uses

Used as a solvent for coatings, especially vinyl resins applied by roller; also used as a chemical intermediate and a solvent for other materials; [ACGIH]

Comments

Liquid causes first degree burns on short exposure. [CHRIS] Isophorone is a skin irritant. [Quick CPC]

Reference Link #1

Biomedical References

Insufficient data

5 ppm

25 ppm

2 ppm

200 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1971] report that exposure of animals for 1 hour to 880 ppm caused serious organ damage; only 1 of 6 animals died from an 8­hour exposure to air saturated with isophorone (approximately 525 ppm at 77°F). . . . Human data: A few of the 11 or 12 volunteers exposed for a few minutes to 200 or 400 ppm complained of nausea, headache, dizziness, faintness, inebriation, and a feeling of suffocation [Smyth and Seaton 1940].

0.438 mm Hg

0.19 ppm

Odor Threshold High

0.53 ppm

27 ppm

LC50 (rat) = 7,000 mg/m3/4h

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.19 ppm); Flash point = 84 deg C; VP from HSDB;

Reference Link #2

high ambient temp required

Acute solvent syndrome

Skin burns

Possible (2b)

Confirmed Animal

Diseases

Occupational diseases associated with exposure to this agent:

• Encephalopathy, chronic solvent
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Painting (Solvents)