Trifluoroacetic acid
Agent Name
Trifluoroacetic acid
Alternative Name
Perfluoroacetic acid
CAS Number
76-05-1
Formula
C2-H-F3-O2
Major Category
Other Classes
Synonyms
Kyselina trifluoroctova [Czech]; Trifluoracetic acid; Trifluoroethanoic acid; Acetic acid, 2,2,2-trifluoro-; Acetic acid, trifluoro-; Perfluoroacetic acid; [ChemIDplus] UN2699
Category
Organic Acids
Description
Colorless fuming liquid with a pungent odor; [ICSC] Hygroscopic; [HSDB]
Sources/Uses
Used in synthesis of organic chemicals; [Merck Index] Used as a laboratory reagent, solvent, and catalyst; [HSDB]
Comments
Corrosive to skin; [Quick CPC] Corrosive to skin, eyes, and respiratory tract; Inhalation may cause pulmonary edema; [ICSC] A metabolite of halothane (anesthetic) and trifluoroethanol; Unlike trifluoroethanol, trifluoroacetic acid did not produce testicular toxicity in rats at similar doses; [REPROTOX] Causes dyspnea in inhalation lethal-concentration studies of mice and rats; Causes other liver changes in 10-day oral studies of mice; [RTECS] Harmful by inhalation; Causes severe burns; May cause liver damage; Inhalation of high concentration may cause chemical pneumonitis; [Aldrich MSDS] See "Fluoroacetic acid."
Biomedical References
Exposure Assessment
Vapor Pressure
110 mm Hg
Lethal Concentration
LC50 (rat) = 10,000 mg/m3
Explanatory Notes
VP from HSDB;
Adverse Effects
Toxic Pneumonitis
Yes
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Dermatotoxin
Skin burns
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.