Acridine mustard

Agent Name
Acridine mustard
Alternative Name
ICR 170
CAS Number
146-59-8
Formula
C21-H25-Cl2-N3-O.2Cl-H
Major Category
Other Uses
Acridine mustard formula graphical representation
Synonyms
1,3-Propanediamine, N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-N-ethyl-, 2HCl; 6-Chloro-9-(3-(ethyl-2-chloroethyl)aminopropylamino)-2-methoxyacridine dihydrochloride; 9-(3-(Ethyl(2-chloroethyl)amino)propylamino)-6-chloro-2-methoxyacridine dihydrochloride; ICR 170; ICR-170; 1,3-Propanediamine, N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-N-ethyl-, dihydrochloride; 6-Chloro-9-((3-((2-chloroethyl)ethylamino)propyl)amino)-2-methoxyacridine dihydrochloride; Acridine, 6-chloro-9-(3-(N-(2-chloroethyl)-N-ethylamino)propylamino)-2-methoxy-, dihydrochloride; [ChemIDplus] UN2811
Category
Biochemical Research
Description
Yellow solid; [CAMEO]
Comments
Intravenous LDLo (mouse) = 5 mg/kg; [RTECS] An irritant; Harmful by ingestion, inhalation, and skin absorption; Risk of irreversible adverse health effects; Possible carcinogen; [Acros Organics MSDS] See "Acridine" and "Acridine orange." See "Nitrogen mustard (HN-2)."
Reference Link #1
Highly mutable sites for ICR-170-induced frameshift mutations are associated with potential DNA hairpin structures: studies with SUP4 and other Saccharomyces cerevisiae genes.
Biomedical References
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Exposure Assessment

Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Toxic solid, organic, n.o.s."

Diseases, Processes, and Activities Linked to This Agent

Other Information
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