Phenyl isocyanate

Agent Name
Phenyl isocyanate
CAS Number
103-71-9
Formula
C7-H5-N-O
Major Category
Toxic Gases & Vapors
Phenyl isocyanate formula graphical representation
Synonyms
Benzene, isocyanato-; Carbanil; Fenylisokyanat [Czech]; Isocyanatobenzene; Isocyanic acid, phenyl ester; Karbanil [Czech]; Mondur P; Phenyl carbonimide; Phenylcarbimide; UN2487; [ChemIDplus]
Category
Monoisocyanates
Description
Liquid with an acrid odor; [Merck Index]
Sources/Uses
Used as a chemical intermediate and analytical reagent; [Hawley]
Comments
A lachrymator and strong irritant of the eyes and respiratory tract; [HSDB] No quantitative data from human studies; The lung appears to be the target organ in lethal concentration studies of experimental animals. "The 1-hour LC50 was 12.6 ppm with most deaths recorded 8 to 12 days post-exposure." TLV Basis is upper respiratory tract irritation; Appears to have sensitization potential (skin and respiratory); [ACGIH] Danger of skin and airway sensitization; [MAK] See "Methyl isocyanate" and "Monoisocyanates."
Biomedical References

Exposure Assessment

Skin Designation (ACGIH)
Yes
TIH
Yes
TLV (ACGIH)
0.005 ppm
STEL (ACGIH)
0.015 ppm
Vapor Pressure
2.57 mm Hg
Lethal Concentration
LC50 (rat) = 4.6 ppm/4H
Explanatory Notes
VP from HSDB;

Adverse Effects

Skin Sensitizer
Yes
Asthma
Yes
Lachrymator
Yes
Toxic Pneumonitis
Yes

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent: