Toluene-2,6-diisocyanate

Synonyms

1,3-Diisocyanato-2-methylbenzene; 2,6-Diisocyanato-1-methylbenzene; 2,6-Diisocyanatotoluene; 2,6-TDI; 2-Methyl-meta-phenylene isocyanate; Benzene, 1,3-diisocyanato-2-methyl-; Benzene, 2,6-diisocyanato-1-methyl-; Isocyanic acid, 2-methyl-meta-phenylene ester; 2,6-Toluene diisocyanate; Tolylene 2,6-diisocyanate; UN2078; m-Tolylene diisocyanate; meta-Tolylene diisocyanates; [ChemIDplus]

Category

Diisocyanates

Description

Colorless to pale-yellow liquid with a sharp, acrid odor; [ACGIH]

Sources/Uses

Occupational asthma reported in floor varnishers and in workers manufacturing polyurethane foams and elastomers; [Malo]

Comments

No major toxicological differences between the various isomers and commercial mixtures of TDI; TLV Basis: asthma; pulmonary function; eye irritation; [ACGIH] See "Toluene-2,4-diisocyanate."

Reference Link #1

Biomedical References

Toluene diamine in urine (with hydrolysis) = 5 ug/g creatine at end of shift; [TLVs and BEIs]

Yes

0.001 ppm, inhalable fraction and vapor

0.005 ppm, inhalable fraction and vapor

Ceiling(OSHA) = 0.02 ppm

0.001 ppm

2.5 ppm

0.0209 mm Hg

0.05 ppm

Explanatory Notes

Odor threshold = 50 ppb with about 1/2 of volunteers detecting and identifying the material at 400 ppb; [ACGIH] VP from ChemIDplus;

Reference Link #2

Yes

Yes

Yes

Yes

Yes

Skin burns

Possible (2b)

Anticipated human carcinogen

Confirmed Animal

Diseases

Occupational diseases associated with exposure to this agent:

• Asthma, occupational
• Contact dermatitis, allergic
• Isocyanate HP

Processes

Industrial Processes with risk of exposure:

• Painting (Pigments, Binders, and Biocides)
• Plastic Composites Manufacturing
• Working with Glues and Adhesives