N-Ethylmaleimide
Agent Name
N-Ethylmaleimide
CAS Number
128-53-0
Formula
C6-H7-N-O2
Major Category
Other Uses
Synonyms
Ethylmaleimide; Maleic acid N-ethylimide; Maleimide, N-ethyl-; NEM; 1H-Pyrrole-2,5-dione, 1-ethyl-; [ChemIDplus] 1-Ethyl-1H-pyrrole-2,5-dione; [Merck Index] UN2928
Category
Biochemical Research
Description
Solid; [Merck Index] Colorless crystals; [Sigma-Aldrich MSDS]
Sources/Uses
Used in cancer research; [Merck Index] "A sulfhydryl reagent that is widely used in experimental biochemical studies." [ChemIDplus]
Comments
Causes somnolence and convulsions in oral lethal-dose studies of rats; [RTECS] A strong irritant; A lachrymator when liquid; [Merck Index] Causes burns; May cause skin sensitization; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Highly toxic by ingestion; Toxic by skin absorption; [Sigma-Aldrich MSDS] Search for 128-53-0 AND (sensitizer OR sensitization OR allergic): no results; [PubMed]
Biomedical References
Exposure Assessment
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Toxic solid, corrosive, organic, n.o.s."
Adverse Effects
Lachrymator
Yes
Toxic Pneumonitis
Yes
Dermatotoxin
Skin burns
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.