Tetrakis (hydroxymethyl) phosphonium chloride

Synonyms

Phosphonium, tetrakis(hydroxymethyl)-, chloride; Pyroset TKC; Retardol C; THPC; Tetrahydroxymethylphosphonium chloride; Tetrakis(hydroxymethyl)phosphochloride; Tetrakis(hydroxymethyl)phosphonium chloride; Tetrakis-(hydroxymethyl)fosfoniumchlorid [Czech]; Tetramethylolphosphonium chloride; [ChemIDplus]

Category

Phosphorus Compounds

Description

Crystalline solid; [ACGIH] Available commercially as an 80% aqueous solution; [MSDSonline]

Sources/Uses

Used to make crease-resistant and flame-retardant finishes for textiles, e.g., children's sleepwear; [ACGIH] Used as a disinfectant--effective against escherichia coli and staphylococcus aureus, and foot-and-mouth disease virus of cattle; [HSDB]

Comments

Degrades rapidly in the environment in the presence of moisture and sunlight; Tetrakis (hydroxymethyl) phosphonium sulfate (THPS) was a sensitizer in 14 of 20 guinea pigs; Tetrakis (hydroxymethyl) phosphonium chloride (THPC) was also designated a dermal sensitizer; THPS did not inhibit acetylcholinesterase in vitro; Rats and mice given repeated high oral doses have liver damage; 14-day gavage studies at 150 mg/kg body weight caused hind limb paralysis in rats; [ACGIH] Toxic if swallowed; May cause skin irritation and sensitization; May cause respiratory sensitization; [Sigma-Aldrich MSDS] See "Tetrakis (hydroxymethyl) phosphonium sulfate."

Biomedical References

No

2 mg/m3

1.13E-07 mm Hg

Explanatory Notes

VP = 1 mm Hg @ 77 deg F; [CAMEO]

Yes

Other CNS neurotoxin

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Not classifiable

Not Classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Textiles (Printing, Dyeing, or Finishing)
• Using Disinfectants or Biocides