Tetrakis (hydroxymethyl) phosphonium chloride

Agent Name
Tetrakis (hydroxymethyl) phosphonium chloride
CAS Number
124-64-1
Formula
C4-H12-O4-P.Cl
Major Category
Other Classes
Tetrakis (hydroxymethyl) phosphonium chloride formula graphical representation
Synonyms
Phosphonium, tetrakis(hydroxymethyl)-, chloride; Pyroset TKC; Retardol C; THPC; Tetrahydroxymethylphosphonium chloride; Tetrakis(hydroxymethyl)phosphochloride; Tetrakis(hydroxymethyl)phosphonium chloride; Tetrakis-(hydroxymethyl)fosfoniumchlorid [Czech]; Tetramethylolphosphonium chloride; [ChemIDplus]
Category
Phosphorus Compounds
Description
Crystalline solid; [ACGIH] Available commercially as an 80% aqueous solution; [MSDSonline]
Sources/Uses
Used to make crease-resistant and flame-retardant finishes for textiles, e.g., children's sleepwear; [ACGIH] Used as a disinfectant--effective against escherichia coli and staphylococcus aureus, and foot-and-mouth disease virus of cattle; [HSDB]
Comments
Degrades rapidly in the environment in the presence of moisture and sunlight; Tetrakis (hydroxymethyl) phosphonium sulfate (THPS) was a sensitizer in 14 of 20 guinea pigs; Tetrakis (hydroxymethyl) phosphonium chloride (THPC) was also designated a dermal sensitizer; THPS did not inhibit acetylcholinesterase in vitro; Rats and mice given repeated high oral doses have liver damage; 14-day gavage studies at 150 mg/kg body weight caused hind limb paralysis in rats; [ACGIH] Toxic if swallowed; May cause skin irritation and sensitization; May cause respiratory sensitization; [Sigma-Aldrich MSDS] See "Tetrakis (hydroxymethyl) phosphonium sulfate."
Biomedical References

Exposure Assessment

Skin Designation (ACGIH)
No
TLV (ACGIH)
2 mg/m3
Vapor Pressure
1.13E-07 mm Hg
Explanatory Notes
VP = 1 mm Hg @ 77 deg F; [CAMEO]

Adverse Effects

Skin Sensitizer
Yes
Neurotoxin
Other CNS neurotoxin
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
IARC Carcinogen
Not classifiable
ACGIH Carcinogen
Not Classifiable

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent:

Processes