1-Chloro-2-propanol
Agent Name
1-Chloro-2-propanol
CAS Number
127-00-4
Formula
C3-H7-Cl-O
Major Category
Other Classes
Synonyms
1-Chloro-2-hydroxypropane; 1-Chloro-2-propanol; 1-Chloroisopropyl alcohol; Chloroisopropyl alcohol; Propene chlorohydrin; sec-Propylene chlorohydrin; [ChemIDplus] UN2611
Category
Halogenated Alcohols
Description
Colorless liquid with a faintly ethereal odor; [ACGIH]
Sources/Uses
Used as a chemical intermediate; A residue in foods that have been fumigated or cold sterilized with propylene oxide; [ACGIH]
Comments
Causes damage to the liver and other organs in animal feeding studies; Critical Effects: reproductive; genotoxic; [ACGIH] No adverse effects on fertility in a chronic feeding study of rats; Increased testis weights and sperm abnormalities--possible evidence of slight reproductive toxicity; [NTP] General anesthetic effect in lethal dose feeding studies of guinea pigs; [RTECS] An irritant of the skin, eyes, and respiratory tract; [CAMEO] See "2-Chloro-1-propanol."
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
Yes
TLV (ACGIH)
1 ppm
Vapor Pressure
4.9 mm Hg
Lethal Concentration
LC50 (rat) = 1000 ppm/4H
Explanatory Notes
VP from ChemIDplus;
NFPA
high ambient temp required
Adverse Effects
Neurotoxin
Acute solvent syndrome
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Reproductive Toxin
Yes
ACGIH Carcinogen
Not Classifiable
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent: