Phenyl isothiocyanate
Agent Name
Phenyl isothiocyanate
CAS Number
103-72-0
Formula
C7-H5-N-S
Major Category
Nitrogen Compounds
Synonyms
Benzene, isothiocyanato-; Benzene-1-isothiocyanate; Fenylisothiokyanat [Czech]; Isothiocyanatobenzene; Isothiocyanic acid phenyl ester; PITC; Phenylisothiocyanate; Phenyl mustard oil; Phenyl thioisocyanate; Phenylsenfoel [German]; Thiocarbanil; Benzene, isothiocyanato-; Isothiocyanic acid, phenyl ester; [ChemIDplus] UN2927
Category
Isothiocyanates
Description
Liquid; [Merck Index] Colorless liquid; [Sigma-Aldrich MSDS]
Sources/Uses
Used to derive primary and secondary amines, in sequencing of peptides by Edman degradation, and in amino acid analysis by HPLC; [Merck Index]
Comments
Dermal studies of guinea pigs demonstrate severe irritation, good absorption, and sensitization; Effects on thyroid function (decreased serum T4 levels) observed in 4-week oral study of rats; [EPA - PPRTV] Causes burns and lachrymation; May cause skin and respiratory sensitization; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; Targets the kidney and bladder; [Sigma-Aldrich MSDS]
Biomedical References
Exposure Assessment
Vapor Pressure
1.5 mm Hg
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Toxic liquid, corrosive, organic, n.o.s." VP from ChemIDplus;
Adverse Effects
Skin Sensitizer
Yes
Lachrymator
Yes
Toxic Pneumonitis
Yes
Dermatotoxin
Skin burns
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent: