Phenylhydrazine hydrochloride

Synonyms

Hydrazine, phenyl-, hydrochloride; Phenylhydrazin hydrochlorid [German]; Phenylhydrazine monohydrochloride; Phenylhydrazine-HCl; Phenylhydrazinium chloride; Hydrazine, phenyl-, monohydrochloride; [ChemIDplus] UN2572

Category

Hydrazines

Description

White to tan solid with a mild aromatic odor; [CAMEO] White powder; [Alfa Aesar MSDS]

Sources/Uses

Used to make dyes, antipyrine, and nitron (explosives stabilizer); as a reagent for sugars, aldehydes, and ketones; and as a therapeutic hemolytic; [Merck Index]

Comments

Causes cyanosis, corrosion, and weight loss in dermal lethal-dose studies of rabbits; Causes methemoglobinemia, respiratory stimulation, and normocytic anemia in intraperitoneal lethal-dose studies of rats; [RTECS] Overexposure may cause skin sensitization, hemolytic anemia, dyspnea, cyanosis, jaundice, kidney injury, vascular thrombosis, and occupational cancer; [Merck Index] An irritant and chronic poison; Ingestion may cause jaundice, anorexia, nausea, vascular thrombosis, anemia, and liver injury; [CHRIS] A skin and strong eye irritant; May cause skin sensitization; Toxic by ingestion, inhalation, and skin absorption; Risk of irreversible adverse health effects; Suspected to cause genetic defects and cancer; [Alfa Aesar MSDS] See "Phenylhydrazine."

Biomedical References

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Phenylhydrazine."

Hemolytic anemia

Yes

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic