Phenylmethylsulfonyl fluoride
Agent Name
Phenylmethylsulfonyl fluoride
Alternative Name
PMSF
CAS Number
329-98-6
Formula
C7-H7-F-O2-S
Major Category
Other Uses
Synonyms
Benzenemethanesulfonyl fluoride; Benzylsulfonyl fluoride; Benzylsulphonyl fluoride; PMSF; Phenylmethanesulfonyl fluoride; alpha-Toluenesulfonyl fluoride; alpha-Toluenesulphonyl fluoride; [ChemIDplus] UN2928
Category
Biochemical Research
Description
Colorless solid; [Merck Index] White crystals; [Sigma-Aldrich MSDS]
Sources/Uses
A serine and cysteine protease inhibitor; Used as a protease inhibitor in research and to prevent proteolytic degradation in protein purification; [Merck Index]
Comments
Causes convulsions and multiple enzyme effects in acute intraperitoneal studies of mice; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion; Targets the nerves, heart, blood, and eyes; [Sigma-Aldrich MSDS] See "Methanesulfonyl fluoride."
Biomedical References
Exposure Assessment
BEI
Fluorides in urine = 2 mg/L prior to shift or 3 mg/L at end of shift; (Repeated measurements recommended.)
TLV (ACGIH)
2.5 mg/m3, as F
PEL (OSHA)
2.5 mg/m3, as F
MAK
1 mg/m3, inhalable fraction, as F
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Toxic solid, corrosive, organic, n.o.s."
Adverse Effects
Toxic Pneumonitis
Yes
Dermatotoxin
Skin burns
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.