o-Phenylenediamine
Agent Name
o-Phenylenediamine
CAS Number
95-54-5
Formula
C6-H8-N2
Major Category
Nitrogen Compounds
Synonyms
1,2-Benzenediamine; 1,2-Diaminobenzene; 1,2-Fenylendiamin [Czech] 1,2-Benzenediamine; 1,2-Diaminobenzene; 1,2-Fenylendiamin [Czech]; 1,2-Phenylenediamine; 2-Aminoaniline; C.I. 76010; C.I. Oxidation Base 16; CI 76010; CI Oxidation Base 16; OPDA; Orthamine; PODA; SQ 15500; o-Benzenediamine; o-Diaminobenzene; o-Fenylendiamin [Czech]; [ChemIDplus] UN1673
Category
Amines, Aromatic
Description
Colorless to brownish-yellow solid that darkens on exposure to light and air; [CHEMINFO]
Sources/Uses
Used as a chemical intermediate, analytical reagent, and photographic developer; [CHEMINFO]
Comments
At lethal concentrations, exposed animals have seizures and paralysis without anesthesia. [ChemIDplus] Methemoglobinemia is observed in acute animal studies. In subchronic studies, rats have anemia and elevated liver enzymes. "Critical Effects" are irritation; liver; blood; [ACGIH]
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
Insufficient data
TLV (ACGIH)
0.1 mg/m3
Lethal Concentration
LC50 (rat) = 1,873 mg/m3
Explanatory Notes
Melting point = 219 deg F; [CAMEO]
NFPA
must be preheated
Adverse Effects
Methemoglobinemia
MetHgb is secondary toxic effect
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
IARC Carcinogen
Possible (2b)
ACGIH Carcinogen
Confirmed Animal
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: