4-Chloro-2-toluidine
Agent Name
4-Chloro-2-toluidine
Alternative Name
4-Chloro-o-toluidine
CAS Number
95-69-2
Formula
C7-H8-Cl-N
Major Category
Nitrogen Compounds
Synonyms
2-Amino-5-chlorotoluene; 2-Methyl-4-chloroaniline; 3-Chloro-6-aminotoluene; 4-Chloro-2-methylaniline; 4-Chloro-2-methylbenzeneamine; 4-Chloro-2-toluidine; 4-Chloro-6-methylaniline; 4-Chloro-o-toluidine; 5-Chloro-2-aminotoluene; Amarthol Fast Red TR Base; Asymmetric meta-chloro-ortho-toluidine; Azoene Fast Red TR Base; Azoic Diazo Component 11, base; Benzenamine, 4-chloro-2-methyl-; Brentamine Fast Red TR Base; Daito Red Base TR; Deval Red K; Deval Red TR; Diazo Fast Red TRA; Fast Red 5CT Base; Fast Red Base TR; Fast Red TR; Fast Red TR Base; Fast Red TR11; Fast Red TRO Base; Kako Red TR Base; Kambamine Red TR; Mitsui Red TR Base; Red Base Ciba IX; Red Base IRGA IX; Red Base NTR; Red TR Base; Sanyo Fast Red TR Base; Tulabase Fast Red TR; o-Toluidine, 4-chloro-; p-Chloro-o-toluidine; para-Chloro-ortho-toluidine; [ChemIDplus]
Category
Amines, Aromatic
Description
Grayish-white crystalline solid; [IARC]
Sources/Uses
Used in the past to manufacture azo dyes and chlordimeform; [IARC]
Comments
4-Chloro-2-toluidine is known to cause methemoglobinemia in humans. Two of three cohort studies showed high relative risks for workers exposed to this chemical in dye and chlordimeform production. [IARC] Induces genetic damage in germ cells of humans or animals (3A); [MAK]
Restricted
No longer in production or use in most countries since the 1980s; [IARC]
Biomedical References
Exposure Assessment
Vapor Pressure
0.041 mm Hg
Explanatory Notes
VP from ChemIDplus;
Adverse Effects
Methemoglobinemia
MetHgb is secondary toxic effect
Reproductive Toxin
Yes
IARC Carcinogen
Probable (2a)
NTP Carcinogen
Anticipated human carcinogen
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.