Succimer
Agent Name
Succimer
CAS Number
304-55-2
Formula
C4-H6-O4-S2
Major Category
Other Uses
Synonyms
(R*,S*)-2,3-Dimercaptobutanedioic acid; Chemet; DIM-SA; DMS; DMSA; Ro 1-7977; Succimero [INN-Spanish]; Succimerum [INN-Latin]; meso-2,3-Dimercaptosuccinic acid; meso-Dimercaptosuccinic acid; Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel-; Butanedioic acid, 2,3-dimercapto-, (R*,S*)-; Succinic acid, 2,3-dimercapto-, meso-; [ChemIDplus] (2R,3S)-rel-2,3-Dimercaptobutanedioic acid; [Merck Index] Meso 2,3-dimercaptosuccinic acid; Meso DMSA; meso-2,3-Dithiosuccinic acid; [RTECS]
Category
Chelating Agents
Description
White solid; [Merck Index] Unpleasant mercaptan odor; [HSDB] White powder with a stench; [Alfa Aesar MSDS]
Sources/Uses
Used as a chelating agent, antidote for metal poisoning, and radioactive imaging agent (in a complex with technetium-99m); [Merck Index]
Comments
Developmental toxicity and teratogenicity observed at doses showing no overt maternal toxicity in mice exposed subcutaneously during gestation; Skeletal anomalies observed in a similar study (not ameliorated by zinc supplementation); [HSDB] Causes organ changes (brain, liver, kidney, and bladder), changes in concentrations of metals, multiple enzyme effects, and changes in leukocyte counts in repeated-dose oral studies of rats; [RTECS] A skin and strong eye irritant; Possible risk of impaired fertility and harm to the unborn child; [Alfa Aesar MSDS]
Biomedical References
Exposure Assessment
Adverse Effects
Reproductive Toxin
Yes
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.