2,4-Di-tert-butylphenol
Agent Name
2,4-Di-tert-butylphenol
CAS Number
96-76-4
Formula
C14-H22-O
Major Category
Other Classes
Synonyms
1-Hydroxy-2,4-di-tert-butylbenzene; Antioxidant No. 33; Phenol, 2,4-di(1,1-dimethylethyl)-; Prodox 146; Prodox 146A-85X; Phenol, 2,4-bis(1,1-dimethylethyl)-; Phenol, 2,4-di-tert-butyl-; [ChemIDplus] 2,4-Bis(1,1-dimethylethyl)phenol; 2,4-Bis(1,1-dimetiletil)fenolo; 2,4-Bis(tert-butyl)phenol; 2,4-Di-tert-butylhydroxybenzene; [IUCLID] UN2430
Category
Phenols
Description
Solid; [EPA ChAMP: Hazard Characterization] Yellow or white crystalline solid; [Sigma-Aldrich MSDS]
Sources/Uses
Used as an antioxidant; [REPROTOX] Used in the chemical and fuel industries; Used as an intermediate and stabilizer; [IUCLID] Used to make phenolic antioxidants and UV stabilizers; [CPS&Q - Summary Fact Sheet] Used as a stabilizer in manufacture and formulation, fuel additive, and intermediate; [ECHA REACH Registrations]
Comments
Di- and tri-substituted mixed alkylphenols: Category members demonstrate moderate skin irritation; Low acute oral and moderate acute dermal toxicity; Evidence of liver toxicity in repeated-dose oral studies of rats; Developmental toxicity at doses producing marginal systemic toxicity in adults; No evidence of reproductive toxicity, mutagenicity, or carcinogenicity; [EPA ChAMP: Hazard Characterization] Reported oral LD50 (rat) values of 3,250 and 1,300 mg/kg; A skin and eye irritant in rabbits; Not a skin sensitizer in guinea pig maximization test; Identified in samples of rubber most often used by employees in hydraulic pump manufacturing diagnosed with cutaneous depigmentation (vitiligo); [IUCLID] Histopathological changes of the liver and kidney observed in 28-day oral study of rats; NOEL's of 75 mg/kg/day in males and 20 mg/kg/day in females; [JECDB] An irritant that may cause serious eye injury; [Sigma-Aldrich MSDS] See "Clorophene."
Biomedical References
Exposure Assessment
Vapor Pressure
0.0075 mm Hg
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Alkyl phenols, solid, n.o.s. (including C2-C12 homologues)."
Adverse Effects
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.