3,5-Xylidine

Synonyms

1-Amino-3,5-dimethylbenzene; 3,5-Dimethylaniline; 3,5-Dimethylbenzenamine; 3,5-Dimethylbenzeneamine; 3,5-Dimethylphenylamine; 3,5-Xylylamine; 5-Amino-1,3-dimethylbenzene; 5-Amino-1,3-xylene; Benzene, 1-amino-3,5-dimethyl-; Benzenamine, 3,5-dimethyl-; [ChemIDplus] 5-Amino-m-xylene; [ICSC] 3,5-Dimethyl-1-aminobenzene; m-Xylidine; [CAMEO] 3,5-DMA; [NTP] UN1711

Category

Amines, Aromatic

Description

Clear light yellow liquid; Turned reddish to brown by air; mp = 9.8 deg C; [ICSC] Light brown liquid; [Alfa Aesar MSDS]

Sources/Uses

Used mainly in dye manufacture; Also used as reagents in synthetic organic chemistry; [Merck Index] Used to make pharmaceuticals, azo dyes, curing agents, antioxidants, antiozonants, additives and detergents for gasoline, wood preservatives, wetting agents for textiles, frothing agents for ore dressing, special lacquers, and metal complexers; [NTP] Used to make fine chemicals; [ECHA REACH Registrations]

Comments

Heavy exposure can cause methemoglobinemia and lowering of consciousness; Chronic exposure may cause anemia; Can be absorbed through skin; [ICSC] Erythrocyte hemolysis, significantly increased methemoglobin levels, and liver and kidney injury observed in sub-chronic oral studies of rats; May cause irritation, headache, drowsiness, cyanosis, confusion, convulsions, and other nervous system and blood effects; [NTP] Toxic by ingestion, inhalation, and skin absorption; Prolonged or repeated exposure may cause kidney and liver injury; [ECHA REACH Registrations] An irritant; Toxic by ingestion, inhalation, and skin absorption; May induce methemoglobinemia; [Alfa Aesar MSDS] See "Xylidine, mixed isomers."

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Yes

0.5 ppm, inhalable fraction and vapor

5 ppm

50 ppm

0.128 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Xylidines."

must be preheated

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Other Information

No other related information on this agent was found.