4-Methylcyclohexanone
Agent Name
4-Methylcyclohexanone
CAS Number
589-92-4
Formula
C7-H12-O
Major Category
Solvents
Synonyms
4-Methyl-1-cyclohexanone; Methyl-4 cyclohexanone-1 [French]; Cyclohexanone, 4-methyl-; [ChemIDplus] Tetrahydro-p-cresol; [Sigma-Aldrich MSDS] UN2297
Category
Ketones (<C12)
Description
Clear light yellow liquid; [Sigma-Aldrich MSDS]
Sources/Uses
Used as a flavoring agent; [FDA]
Comments
TLV Basis is liver effects and CNS impairment. TLV-TWA is 20 ppm for Methylcyclohexanone (mixture of the 3 isomers), CAS number 1331-22-2. Causes liver toxicity in feeding study of rats. [ACGIH] Causes change in cardiac rate and lowered blood pressure in intravenous lethal-dose studies of dogs; [RTECS] Safe when used as a flavoring agent in food; [JECFA] May cause irritation; Harmful by ingestion; [Sigma-Aldrich MSDS]
Biomedical References
Exposure Assessment
TLV (ACGIH)
20 ppm
Vapor Pressure
1.5 mm Hg
Adverse Effects
Neurotoxin
Acute solvent syndrome
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent: