Enflurane

Synonyms

(+-)-2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether; 2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether; 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane; Anesthetic 347; Anesthetic Compound No. 347; C 347; Compound 347; Efrane; Enflurane; Enflurano [INN-Spanish]; Enfluranum [INN-Latin]; Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-; Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-, (+-)-; Ethrane; Methylflurether; OHIO 347; [ChemIDplus]

Category

Waste Anesthetic Gases

Description

Clear, colorless liquid with a mild, sweet odor; inhalation anesthetic; [NIOSH]

Sources/Uses

Stable inhalation anesthetic; [ChemIDplus]

Comments

See "WASTE ANESTHETIC GASES" Enflurane is in the list of "Some volatile substances which may be abused by inhalation" published on the web site of the U.N. International Drug Control Programme, indicating its potential to cause narcosis in workers. [Reference #1] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC] Occupational asthma confirmed in a hospital worker; [Malo]

Reference Link #1

Biomedical References

Insufficient data

75 ppm

20 ppm

591 mm Hg

LC50 (rat) = 14,000 ppm/3h

Reference Link #2

Yes

Acute solvent syndrome

Yes

Not Classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Asthma, occupational
• Solvents, acute toxic effect