Mitomycin C
Agent Name
Mitomycin C
CAS Number
50-07-7
Formula
C15-H18-N4-O5
Major Category
Other Uses
Synonyms
6-Amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methylazirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione carbamate (ester); 7-Amino-9alpha-methoxymitosane; Ametycin; Ametycine; Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))-; Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))-; (9CI); MMC; Mitocin-C; Mitomycin; Mitomycin C; Mitomycin-C; Mitomycinum; Mitomycinum C; Mitomycyna C [Polish]; Mitozytrex; Mutamycin; Mytomycin; Mytozytrex; [ChemIDplus] UN2811
Category
Pharmaceuticals
Description
Water-soluble crystals that are blue-violet; [CAMEO]
Sources/Uses
Used as an alkylating agent in cancer chemotherapy; [HSDB]
Comments
"Toxic doses as low as 750 mg/kg have been reported in humans. The major toxic effect is myelosuppression, characterized by marked leukopenia and thrombocytopenia; this may be delayed and cumulative. Interstitial pneumonia and glomerular damage resulting in kidney failure are unusual but well documented complications. Lung conditions -- administration of mitomycin has been recognized as causing pneumonitis, alveolitis and pulmonary fibrosis. Kidney conditions -- administration of mitomycin can cause kidney damage. Kidney toxicity was observed in 1-5 percent of patients." [CAMEO]
Biomedical References
Adverse Effects
IARC Carcinogen
Possible (2b)
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.