1-Methylpiperazine
Agent Name
1-Methylpiperazine
CAS Number
109-01-3
Formula
C5-H12-N2
Major Category
Nitrogen Compounds
Synonyms
4-Methylpiperazine; N-Methylpiperazine; Piperazine, 1-methyl-; [ChemIDplus] UN2734
Category
Piperazines
Description
Clear light yellow hygroscopic liquid; [Sigma-Aldrich MSDS]
Sources/Uses
Used to make large scale and fine chemicals; [ECHA REACH Registrations]
Comments
Causes skin corrosion in acute dermal studies of rabbits; Causes convulsions in acute inhalation studies of mice; Causes multiple liver effects, changes in renal tubules, changes in recording from peripheral motor nerve, and general anesthesia in acute oral studies of mice; [RTECS] Causes burns; May cause skin sensitization; Harmful by inhalation; [ECHA REACH Registrations] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by skin absorption; Toxic by inhalation; [Sigma-Aldrich MSDS] See "Piperazine and salts."
Biomedical References
Exposure Assessment
Vapor Pressure
3 mm Hg
Lethal Concentration
LC50 (mouse) = 2,740 mg/m3/2hr
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Amines, liquid, corrosive, flammable, n.o.s."
NFPA
high ambient temp required
Adverse Effects
Skin Sensitizer
Yes
Toxic Pneumonitis
Yes
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Dermatotoxin
Skin burns
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent: