Endrin

Synonyms

1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-endo,endo-5,8-dimethanonaphthalene; Hexadrin; [NIOSH]

Category

Organochlorine Pesticides

Description

Colorless to tan, crystalline solid with a mild, chemical odor. [insecticide]; [NIOSH]

Sources/Uses

Formerly used as an insecticide, as an avicide, and as a rodenticide; [HSDB]

Comments

High-dose animal studies show that organochlorine insecticides can cause liver injury. [LaDou, p. 593] "No evidence of hepatic injury in humans as the result of environmental contamination." [Zimmerman, p. 414]

Voluntary cancellation in 1985; all U.S. registrations cancelled; [EPA Pesticides, p. 56]

Biomedical References

Yes

Yes

0.1 mg/m3

0.1 mg/m3

0.05 mg/m3, inhalable fraction

2 mg/m3

Excerpts from Documentation for IDLHs

Human data: An oral dose of 171 mg/kg has been reported to be lethal [Runhaar et al. 1985]. It has also been reported that the approximate oral dose producing convulsions is about 0.2 mg/kg [Hayes 1982]. [Note: Oral doses of 171 mg/kg or 0.2 mg/kg are equivalent to a 70­kg worker being exposed to about 8,000 mg/m3 or 9 mg/m3, respectively, for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

3E-06 mm Hg

No reports found; [TDR, p. 613]

Reference Link #2

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Not classifiable

Not Classifiable

Other Poison

Organochlorine

Diseases

Occupational diseases associated with exposure to this agent:

• Organochlorine insecticides, acute poisoning