Phosdrin

Synonyms

(2-Methoxycarbonyl-1-methyl-vinyl)-dimethyl-fosfaat [Dutch]; (2-Methoxycarbonyl-1-methyl-vinyl)-dimethyl-phosphat [German]; (2-Metossicarbonil-1-metil-vinil)-dimetil-fosfato [Italian]; 1-Methoxycarbonyl-1-propen-2-yl dimethyl phosphate; 2-Butenoic acid, 3-((dimethoxyphosphinyl)oxy)-, methyl ester; 2-Carbomethoxy-1-methylvinyl dimethyl phosphate; 2-Carbomethoxy-1-propen-2-yl dimethyl phosphate; 2-Methoxycarbonyl-1-methylvinyl dimethyl phosphate; 3-((Dimethoxyphosphinyl)oxy)-2-butenoic acid methyl ester; 3-Hydroxycrotonic acid methyl ester dimethyl phosphate; CMDP; Compound 2046; Crotonic acid, 3-hydroxy-, methyl ester, dimethyl phosphate; Dimethyl (1-methoxycarboxypropen-2-yl)phosphate; Dimethyl 2-methoxycarbonyl-1-methylvinyl phosphate; Dimethyl methoxycarbonylpropenyl phosphate; Dimethyl phosphate of methyl 3-hydroxy-cis-crotonate; Dimethyl-1-carbomethoxy-1-propen-2-yl phosphate; Duraphos; Fosdrin; Gesfid; Meniphos; Menite; Methyl 3-((dimethoxyphosphinyl)oxy)-2-butenoate (9CI); Methyl 3-(dimethoxyphosphinoyloxy)but-2-enoate; Methyl 3-(dimethoxyphosphinyloxy)crotonate; Methyl 3-hydroxy-alpha-crotonate dimethyl phosphate; Methyl 3-hydroxycrotonate dimethyl phosphate ester (8CI); Methyl-3-hydroxy-alpha-crotonate, dimethyl phosphate ester; Mevinfos [Dutch]; Mevinphos; O,O-Dimethyl 1-carbomethoxy-1-propen-2-yl phosphate; O,O-Dimethyl O-(1-methyl-2-carboxyvinyl) phosphate; O,O-Dimethyl-O-(2-carbomethoxy-1-methylvinyl) phosphate; O,O-Dimethyl-O-2-methoxycarbonyl-1-methyl-vinyl-phosphat [German]; OS 2046; PD 5; PD 5 (pesticide); Phosfene; Phosphate de dimethyle et de 2-methoxycarbonyl-1 methylvinyle [French]; Phosphoric acid, (1-methoxycarboxypropen-2-yl) dimethyl ester; Phosphoric acid, dimethyl ester, ester with methyl 3-hydroxycrotonate; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Pale-yellow to orange liquid with a weak odor; [NIOSH]

Sources/Uses

Used to kill insects on vegetables, alfalfa, fruits, and nuts; [HSDB]

Comments

It is applied 1-10 days before harvest; it dissipates quickly. [HSDB] Skin sensitization occurs rarely. [Kanerva, p. 1817] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

Reference Link #1

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Yes

0.01 mg/m3, inhalable fraction and vapor

0.1 mg/m3

0.093 mg/m3

36 mg/m3

0.003 mm Hg

LC50 (rat) = 14 ppm/1h

Yes

Not Classifiable

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)