1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin

Synonyms

1,2,3,7,8,9-Hexachlorodibenzo(b,e)(1,4)dioxin; D 70; Dibenzo-p-dioxin, 1,2,3,7,8,9-hexachloro-; [ChemIDplus]

Category

Halogenated Polyaromatics

Description

Light pink solid; [CAMEO] Orange powder; [MSDSonline]

Sources/Uses

Found in emissions from waste incineration, PCB’s, automobiles (using leaded gas), and improper waste disposal of some chlorinated compounds; Not commercially produced; [HSDB] Hexachlorodibenzo-p-dioxins (HCDD): Found as impurities in polychlorinated phenols and chlorophenol derivative herbicides (i.e. 2,4-D); [NTP]

Comments

Can cause chloracne and liver injury; [CAMEO] Polychlorodibenzodioxins have caused chloracne in humans; Oral LD50 (rat) = 1.8 (male) and 0.8 (female) mg/kg bw (31% 1,2,3,6,7,8- and 67% 1,2,3,7,8,9-hexachlorodibenzo-p-dioxins); [HSDB] No evidence of carcinogenicity in mice with dermal application, but carcinogenic effects, including hepatocellular carcinomas, observed in gavage study with rats and mice (mixture of 1,2,3,6,7,8- and 1,2,3,7,8,9-hexachlorodibenzo-p-dioxins); [NTP] IARC classification is for polychlorinated dibenzo-para-dioxins other than 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD);

Biomedical References

4.88E-11 mm Hg

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Chloracne

Not classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Chloracne