1,2-Dibromo-3-chloropropane

Synonyms

Dibromochloropropane; DBCP; [NIOSH]

Category

Fumigants

Description

Dense yellow or amber liquid with a pungent odor at high concentrations. [pesticide] [Note: A solid below 43 degrees F.] [NIOSH]

Comments

Strong positive data for testicular damage in animals and decreased sperm counts, azoospermia, and hormonal changes in humans; [ATSDR Case Studies # 29] "Germ cell mutagens that have shown to increase the mutant frequency in the progeny of exposed mammals." [MAK]

All uses except on pineapple plantations in Hawaii canceled in 1979; use on pineapples cancelled in 1985; See 29CFR1910.1044;

Biomedical References

0.001 ppm

0.8 mm Hg

LC50 (rat) = 103 ppm/8H

Explanatory Notes

VP = 0.58 mm Hg at 20 deg C; [HSDB]

Animal studies: 80% of absorbed dose eliminated within 24 hours; [TDR, p. 479]

Reference Link #2

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Possible (2b)

Anticipated human carcinogen

Diseases

Occupational diseases associated with exposure to this agent:

• Fumigants, acute toxic effect
• Infertility, male

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)