Allyl chloride

Synonyms

3-Chloropropene; 1-Chloro-2-propene; 3-Chloro-1-propene; 3-Chloropropylene; Chloroallylene; [NIOSH]

Category

Chlorinated Aliphatics

Description

Colorless, brown, yellow, or purple liquid with a pungent, unpleasant odor; [NIOSH] Odor is similar to garlic; [ACGIH]

Sources/Uses

Used in the manufacture of organic chemicals; [ACGIH] Used to make glycerin and epoxy resin; [Rosenstock, p. 676]

Comments

Liquid causes first degree burns on short exposure; [CHRIS] Corrosive to skin; [Quick CPC] Probably a mild eye irritant based on animal studies; [CHEMINFO] Experimental animals suffer no apparent adverse effects after being exposed to 3 ppm, 7 hours/day, 5 days/week for 6 months. Causes liver and kidney damage in subcutaneous lethal dose studies; In acute inhalation exposure studies at concentrations varying from 200 to 2000 ppm, dose dependent kidney damage is observed in rat and mice; Kidney and peripheral nerve injury is observed in mice given 300-500 mg/kg orally 3 times a week for 2-17 weeks. Human volunteers reported odor but no irritation after exposure to 3 ppm for 1-3 minutes; No elevations of kidney or liver function tests were found in a study of 73 males producing chlorinated hydrocarbons and exposed to allyl chloride for an average of 8.2 years; Peripheral neuropathy was reported in 53% of factory workers chronically exposed to allyl chloride. [ACGIH] "Cessation of exposure usually results in good recovery." [Rosenstock, p. 676] Pulmonary edema may result from inhalation of high concentrations. [NJ-HSFS]

Reference Link #1

Biomedical References

Yes

1 ppm

2 ppm

1 ppm

250 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH. . The chosen IDLH is based on the statement by Deichmann and Gerarde [1969] that a 1-hour exposure to 300 ppm might cause serious effects.

368 mm Hg

0.48 ppm

Odor Threshold High

5.9 ppm

2330 ppm

LC50 (rat) = 2000 ppm/4H

Explanatory Notes

Odor threshold from AIHA; Flash point equals -25 deg F; [CHEMINFO] VP from HSDB;

No reports found; [TDR, p. 67]

Reference Link #2

may ignite at ambient temp

3 ppm

40 ppm

300 ppm

Yes

Sensorimotor

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Skin burns

Not classifiable

Confirmed Animal

Diseases

Occupational diseases associated with exposure to this agent:

• Neuropathy, toxic