1-Bromo-3-chloropropane

Synonyms

1,3-ChBP; 1-Chloro-3-bromopropane; 3-Bromo-1-chloropropane; 3-Bromopropyl chloride; 3-Chloro-1-bromopropane; 3-Chloropropyl bromide; Propane, 1-bromo-3-chloro-; Trimethylene bromide chloride; Trimethylene chlorobromide; omega-Chlorobromopropane; [ChemIDplus] UN2688

Category

Halogenated Aliphatics, Saturated

Description

Colorless liquid; [HSDB]

Sources/Uses

Used as a chemical intermediate for organic synthesis (i.e. pharmaceuticals); [HSDB]

Comments

May cause CNS effects and liver injury; [ICSC] No significant adverse gross or histopathological changes observed with regard to body weight, kidneys, or male reproductive organs in two week feeding study with rats; Emergency medical treatment: see Dibromochloropropane; [HSDB] A strong eye and respiratory tract irritant; [CAMEO] Observations in four hour inhalation study with rats include pulmonary hemorrhages, fatty degeneration of the liver and heart, albuminoid degeneration of the kidney, and edema and swelling of brain neural tissue; No gross or histopathological changes observed in another inhalation study; Classified as not irritating to skin and eyes of rabbits (some corneal opacity and conjunctival irritation/redness observed, but cleared by day 8 in all studies); Observations in 24 day study with rats include liver degeneration, increased frequency of chromosomal aberrations in bone marrow, and decrease in testicular weight coefficient and spermatozoa motility; Not mutagenic to various Salmonella typhimurium strains; No significant adverse effects to male reproductive system observed in five week feeding or two week gavage studies with rats; [IUCLID]

Biomedical References

6.38 mm Hg

LC50 (rat) = 5,668 mg/m3

Explanatory Notes

Flash point = 57 deg C; [eChemPortal: IUCLID]

Other CNS neurotoxin

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Possible (2b)

Other Information

No other related information on this agent was found.