1-Chloro-2,4-dinitrobenzene

Synonyms

Dinitrochlorobenzene; 1,3-Dinitro-4-chlorobenzene; 1-Chloor-2,4-dinitrobenzeen [Dutch]; 1-Chlor-2,4-dinitrobenzene; 1-Chlor-2,4-dinitrobenzol; 1-Chloro-2,4-dinitrobenzeen [Dutch]; 1-Chloro-2,4-dinitrobenzol [German]; 1-Cloro-2,4-dinitrobenzene [Italian]; 2,4-Dinitro-1-chlorobenzene; 2,4-Dinitrochlorobenzene; 2,4-Dinitrophenyl chloride; 4-Chloro-1,3-dinitrobenzene; 6-Chloro-1,3-dinitrobenzene; Benzene, 1-chloro-2,4-dinitro-; CDNB; Chlorodinitrobenzene; DNCB; Dinitrochlorobenzene (VAN); Dinitrochlorobenzol; [ChemIDplus] UN1577

Category

Nitros, Aromatic

Description

Yellow solid with an almond odor; [HSDB] Crystalline powder; [MSDSonline]

Sources/Uses

Used as a reagent for the detection and determination of pyridine compounds; in the manufacture of azo dyes; as an algicide in coolant water; as an immunostimulant in leprosy and some forms of cancer; and in the treatment of alopecia and warts; [HSDB]

Comments

Emergency treatment: Methemoglobinemia; May cause retrobulbar neuritis and loss of vision after chronic exposure; [HSDB] May cause allergic dermatitis; [Merck Index] A skin, eye, and respiratory tract irritant; May cause skin sensitization; Can induce methemoglobinemia; May cause nervous system injury resulting in impaired vision; [ICSC] Toxic by inhalation, ingestion, and skin absorption; [CAMEO] Dinitrochlorobenzene (DNCB) is a potent contact allergen that has been used in the treatment of alopecia areata and cutaneous metastasis of malignant melanoma; [Kanerva, p. 1787] An irritant; May cause skin sensitization; Effects in high-dose animal studies include methemoglobinemia, carboxyhemoglobin, convulsions or effect on seizure threshold, and other degenerative changes to brain; [MSDSonline]

Biomedical References

8.5E-05 mm Hg

Explanatory Notes

Flash point = 179 deg C; [ICSC]

must be preheated

Yes

MetHgb is secondary toxic effect

Other CNS neurotoxin

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic