1-Chloro-2,6-dinitrobenzene

Agent Name
1-Chloro-2,6-dinitrobenzene
CAS Number
606-21-3
Formula
C6-H3-Cl-N2-O4
Major Category
Nitrogen Compounds
1-Chloro-2,6-dinitrobenzene formula graphical representation
Synonyms
1,3-Dinitro-2-chlorobenzene; 2,6-Dinitrochlorobenzene; 2-Chloro-1,3-dintrobenzene; Benzene, 2-chloro-1,3-dinitro-; [ChemIDplus] UN1577
Category
Nitros, Aromatic
Description
Yellow solid; [Merck Index] Yellow crystals; [MSDSonline]
Sources/Uses
Used as an intermediate in the manufacture of picric acid; Has been used as a topical adjuvant in immunotherapy of tumors; [HSDB]
Comments
Emergency treatment: "Nitrobenzene." [HSDB] May cause primary and allergic dermatitis; A skin irritant; [Merck Index] Dinitrochlorobenzene (DNCB) is a potent contact allergen that has been used in the treatment of alopecia areata and cutaneous metastasis of malignant melanoma; [Kanerva, p. 1787] An irritant; [MSDSonline] See "1-Chloro-2,4-dinitrobenzene."
Biomedical References

Exposure Assessment

Adverse Effects

Skin Sensitizer
Yes
Methemoglobinemia
MetHgb is secondary toxic effect
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent: