o-Anisidine

Synonyms

1-Amino-2-methoxybenzene; 2-Aminoanisole; 2-Anisidine; 2-Methoxy-1-aminobenzene; 2-Methoxyaniline; 2-Methoxybenzenamine; Benzenamine, 2-methoxy-; o-Aminoanisole; o-Anisylamine; o-Methoxyaniline; o-Methoxyphenylamine; ortho-Aminoanisole; ortho-Methoxyaniline; ortho-Methoxyphenylamine; [ChemIDplus] UN2431

Category

Amines, Aromatic

Description

Red or yellow, oily liquid with an amine-like odor; Note: A solid below 41 degrees F; [NIOSH]

Sources/Uses

Used in the synthesis of azo dyes and guaiacol; [ACGIH]

Comments

Hematologic changes, anemia, nephrotoxicity, and bladder cancer occur in animal studies. Workers exposed at 0.4 ppm for 3.5 hours/day for six months did not develop anemia, but did have methemoglobinemia and Heinz bodies as well as complaints of headache and vertigo. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] Evidence of liver injury in high-dose feeding studies of rats; [HSDB] See 2021 (Volume 127) monograph at IARC.

Reference Link #1

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Yes

0.5 mg/m3

0.5 mg/m3

50 mg/m3

Excerpts from Documentation for IDLHs

Other animal data: Mice have survived exposures to concentrations of 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month with only a decrease in the excitability of nerves noted [Zaeva and Fedorova 1962]. Human data: None relevant for use in determining the revised IDLH.

0.08 mm Hg

Explanatory Notes

Flash point = 118 deg C; VP from HSDB;

must be preheated

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Probable (2a)

Confirmed Animal

Other Information

No other related information on this agent was found.