2-Bromopropane

Synonyms

2-Bromopropane; Isopropyl bromide; Propane, 2-bromo-; UN2344; [ChemIDplus] 2-BP; [ACGIH]

Category

Brominated Solvents

Description

Clear liquid; [Hawley]

Sources/Uses

Used as a freon substitute; [ChemIDplus] Used in organic synthesis; [Hawley]

Comments

In 1995, an outbreak was reported in Korean electronics workers using 2-BP to degrease switches. Adverse effects were amenorrhea and severe anemia in 17/25 females and oligospermia or azospermia in 6/8 males. The work area concentration was 12.4 ppm, and some workers had skin contact. In a Chinese plant manufacturing 2-BP, 25 workers were studied. Four females exposed at >10 ppm had amenorrhea or polymenorrhea. [ACGIH] See "1-Bromopropane."

Biomedical References

216 mm Hg

LC50 (mouse) = 31,171 ppm/4H

Explanatory Notes

BP = 59.5 deg C; [ChemIDplus]

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Diseases

Occupational diseases associated with exposure to this agent:

• Infertility, female
• Infertility, male
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Metal Degreasing