2-Methoxy-1,4-benzenediamine

Synonyms

1,4-Benzenediamine, 2-methoxy-; 2,5-Diaminoanisole; 2-Methoxy-p-phenylenediamine; 2-MPPD; p-Diaminoanisole; p-Phenylenediamine, 2-methoxy-; [ChemIDplus]

Category

Amines, Aromatic

Sources/Uses

Used as a component in hair dyes; [HSDB]

Comments

Reproductive effects in 8-week IP study with rats include decrease in number of pregnancies and live fetuses; Emergency treatment: "Paraphenylenediamine"; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] See "p-Phenylenediamine."

Biomedical References

0.00132 mm Hg

Yes

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Dressing Hair