2-Picoline
Agent Name
2-Picoline
CAS Number
109-06-8
Formula
C6-H7-N
Major Category
Nitrogen Compounds
Synonyms
alpha-Picoline; 2-Methylpyridine; AI3-24109; PICOLINE, ALPHA; Picoline; Pyridine, 2-methyl-; alpha-Methylpyridine; o-Picoline; [ChemIDplus] UN2313
Category
Pyridines
Description
Colorless liquid with a strong unpleasant odor; [Hawley] Colorless or yellow tinted clear liquid; [MSDSonline]
Sources/Uses
Used as an intermediate (dyes, resins, agrochemicals, and pharmaceuticals), solvent, and laboratory reagent; [HSDB] Found naturally in coal tar; Used as a solvent and to make dyes and resins; [MSDSonline] Picolines are constituents in cigarette smoke, bone oil, coal tar, and coke oven emissions. [AIHA]
Comments
A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation of high concentrations can cause unconsciousness; The liquid defats the skin; [ICSC] An irritant; Harmful if swallowed, inhaled, or absorbed through skin; A strong respiratory tract irritant; May cause convulsions; Oral LD50 (rat) = 790 mg/kg; [MSDSonline] An irritant that can cause CNS depression; Liver changes occur in rats exposed to chronic high doses; [AIHA] See "Pyridine."
Biomedical References
Exposure Assessment
Vapor Pressure
11.2 mm Hg
Odor Threshold Low
0.013 ppm
Odor Threshold High
0.45 ppm
Lethal Concentration
LCLo (rat) = 4,000 ppm/4h
Explanatory Notes
Flash point = 26 deg C; [ICSC] Odor threshold low = 0.05 mg/m3; High = 0.17 mg/m3; [HSDB] The Guide in the Emergency Response Guidebook is for "Picolines." VP from ChemIDplus;
NFPA
may ignite at ambient temp
WEEL
2 ppm, STEL = 5 ppm
Adverse Effects
Neurotoxin
Other CNS neurotoxin
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Dermatotoxin
Skin burns
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.