5,5-Dimethylhydantoin
Agent Name
5,5-Dimethylhydantoin
CAS Number
77-71-4
Formula
C5-H8-N2-O2
Major Category
Nitrogen Compounds
Synonyms
2,4-Imidazolidinedione, 5,5-dimethyl-; 5,5-Dimethyl hydantoin; 5,5-Dimethyl-2,4-imidazolidinedione; DM Hydantoin; DMH; Dantoin 736; Dantoin DMH; Dimethylhydantoin; T10; Hydantoin, 5,5-dimethyl-; [ChemIDplus]
Category
Other Nitrogen Compounds
Description
White solid; [Hawley] White odorless crystalline powder; [Alfa Aesar MSDS]
Sources/Uses
Used as an inert ingredient in pesticides and in the synthesis of water-soluble polymers; [HSDB]
Comments
No compound related effects observed in 13-week dermal study of rats; Increased adrenal weight (with corresponding adrenal cortical hypertrophy) was observed in a one year feeding study of dogs, but no other significant adverse effects observed in long term studies of mice, rats, or dogs; No evidence of developmental toxicity; Two generation gavage study of rats produced decreased pup weights in both generations and decreased mean live litter sizes in the second generation; No evidence of mutagenicity; [HSDB] Decreased testicular and epididymides weights (without corresponding histopathology) observed in 4-week oral (capsule) study of dogs at highest tested dose (2,000 mg/kg/day); 90-day gavage studies of rats produced histopathological changes to kidneys (renal pelvic urolithiasis and chronic interstitial nephritis) and increased kidney weights in mid and high dose animals (5,000 and 10,000 mg/kg/day); No significant adverse effects observed in several other animal studies including a 90-day gavage study of rats (doses up to 2,000 mg/kg/day), 13-week dermal study of rats, 24-month feeding study of rats (doses up to 1,000 mg/kg/day), and 1-year feeding (capsules) study of dogs (up to 1,000 mg/kg/day); No evidence of carcinogenicity in rats or mice; No evidence of mutagenicity; No evidence of adverse effects on reproduction or reproductive tissue in two generational feeding study of rats (doses up to 20,000 ppm); Limited evidence or teratogenicity; [EPA HPVIS] May cause irritation; [Alfa Aesar MSDS] See "DMDM hydantoin."
Biomedical References
Exposure Assessment
Vapor Pressure
2.8E-06 mm Hg
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: