5-Amino-o-cresol
Agent Name
5-Amino-o-cresol
CAS Number
2835-95-2
Formula
C7-H9-N-O
Major Category
Nitrogen Compounds
Synonyms
4-Amino-2-hydroxy-1-methylbenzene; Phenol, 5-amino-2-methyl-; 2-Hydroxy-p-toluidine; 3-Amino-6-methylphenol; 3-Hydroxy-4-methylaniline; 4-Amino-2-hydroxytoluene; 5-Amino-2-methylphenol; 6-Methyl-3-aminophenol; [ChemIDplus]
Category
Amino Phenols
Description
Brown solid; [CAMEO] Slightly beige powder; [MSDSonline]
Sources/Uses
Used as a coupler in oxidative hair dyeing; [HSDB]
Comments
A mutagen; Causes somnolence and ataxia in lethal-dose feeding studies of rats; [RTECS] Induces goiter, hypothyroidism, and liver injury in feeding studies of rats for 13 weeks; No difference in chromosomal aberrations between controls and subjects who dyed their hair with 2-hydroxy-4-aminotoluene 13 times at intervals of 3-6 weeks; Very weak skin sensitizer in guinea pigs; Did not induce photosensensitization in guinea pigs; [HSDB] A skin, eye, and mucous membrane irritant; [CAMEO] An irritant; [MSDSonline]
Biomedical References
Exposure Assessment
Vapor Pressure
0.00026 mm Hg
Adverse Effects
Neurotoxin
Other CNS neurotoxin
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: