5-Chloro-o-toluidine

Synonyms

5-Chloroaminotoluene; 1-Amino-3-chloro-6-methylbenzene; 2-Amino-4-chlorotoluene; 2-Methyl-5-chloroaniline; 3-Chloro-6-methylaniline; 4-Chloro-2-aminotoluene; 5-Chloro-2-methylaniline; 5-Chloro-2-methylbenzenamine; 5-Chloro-2-toluidine; Acco Fast Red KB Base; Ansibase Red KB; Azoene Fast Red KB Base; Azoic Diazo Component 32; C.I. Azoic Diazo Component 32; Fast Red KB Salt; Fast Red KB Salt Supra; Fast Red KB amine; Fast Red KB base; Fast Red KB-T Base; Fast Red KBS Salt; Genazo Red KB Soln; Hiltonil Fast Red KB Base; Lake Red BK Base; Lake Red KB Base; Metrogen Red Former KB Soln; Naphthosol Fast Red KB Base; Pharmazoid Red KB; Red KB Base; Spectrolene Red KB; Stable Red KB Base; o-Toluidine, 5-chloro-; Benzenamine, 5-chloro-2-methyl-; [ChemIDplus] UN2239

Category

Amines, Aromatic

Description

Grayish-white solid; [HSDB] Low melting solid; mp = 20-22 deg C; [MSDSonline]

Sources/Uses

Used in the synthesis of organic dyestuffs; [HSDB]

Comments

Hemorrhagic cystitis and methemoglobinemia were reported in workers handling this chemical to manufacture dyes. Skin absorption was the most likely route of exposure; Causes liver cancer in high-dose feeding studies in experimental animals; [HSDB] An irritant; May induce methemoglobinemia; [MSDSonline]

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

0.041 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Chlorotoluidines, solid." VP from ChemIDplus;

MetHgb is primary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Not classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Methemoglobinemia, acute