Acetoacetanilide

Synonyms

((Acetoacetyl)amino)benzene; 1-(Phenylcarbamoyl)-2-propanone; 3-Oxo-N-phenylbutanamide; Acetanilide, 2-acetyl-; Acetoacetamidobenzene; Acetoacetanilid; Acetoacetanilide; Acetoacetic acid anilide; Acetoacetic anilide; Acetoacetylaniline; Anilid kyseliny acetoctove; Anilid kyseliny acetoctove [Czech]; Butanamide, 3-oxo-N-phenyl-; Butanoic acid, 3-oxo-, amide, N-phenyl-; N-(Acetylacetyl)aniline; N-Phenylacetoacetamide; alpha-Acetyl-N-phenylacetamide; beta-Ketobutyranilide; [ChemIDplus] AAA; [Reference #1]

Category

Other Aromatics (Nitrogen)

Description

White solid; [Hawley] White, odorless crystalline powder; [Alfa Aesar MSDS]

Sources/Uses

Used in rubber compounding and in manufacturing other chemicals (hansa yellow dyes, benzidine yellow pigments, the fungicides carboxin and methfuroxam, and pyrazolones and pyrimidines); [HSDB]

Comments

Reports of reversible eye burns in humans; Not irritating to skin and mildly irritating to eyes of rabbits; No evidence of skin sensitization in guinea pigs; Causes slight methemoglobinemia and significant formation of Heinz bodies in cats following single oral administration of 100 mg/kg; Hemolytic anemia and corresponding injury to liver, spleen, and kidneys observed in 28-day oral study of rats (850 mg/kg/day and, to some extent, at 100 mg/kg/day); Emergency treatment: "Phenacetin"; Phenacetin was used as a pain-relieving drug, but has not been available in the US since 1983. Can cause methemoglobinemia after ingestion >1 gram/day; Can cause renal papillary necrosis following ingestion of large doses for years; [HSDB] A weak allergen; [CAMEO] A mild skin irritant; Can be absorbed through skin; [Alfa Aesar MSDS]

Biomedical References

0.01 mm Hg

Explanatory Notes

Flash point = 162.7 deg C; [Hawley]

must be preheated

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Other Information

No other related information on this agent was found.