Crag herbicide
Agent Name
Crag herbicide
Alternative Name
Sesone
CAS Number
136-78-7
Formula
C8-H7-Cl2-O5-S.Na
Major Category
Pesticides
Synonyms
2,4-Des sodium; 2,4-Des-Na; 2,4-Des-natrium [German]; 2,4-Dichlorophenoxyethyl hydrogen sulfate sodium salt; 2,4-Dichlorophenoxyethyl sulfate, sodium salt; 2-(2,4-Dichlorfenoxy)ethylsiran sodny [Czech]; 2-(2,4-Dichlorophenoxy)ethanol hydrogen sulfate sodium salt; 2-(2,4-Dichlorophenoxy)ethyl sulfate sodium salt; Crag herbicide 1; Crag herbicide I; Disul; Disul-Na; Disul-sodium; Experimental herbicide 1; Experimental herbicide I; Herbon 2,4-des-sodium; Natrium-2,4-dichlorphenoxyathylsulfat [German]; SES; Ses-T; Sesone; Sodium 2,4-dichlorophenoxyethyl sulfate; Sodium 2,4-dichlorophenoxyethyl sulphate; Sodium 2,4-dichlorophenyl cellosolve sulfate; Sodium 2-(2,4-dichlorophenoxy)ethyl sulfate; [ChemIDplus]
Category
Herbicides, Chlorophenoxy
Description
Colorless to white crystalline, odorless solid. [herbicide]; [NIOSH]
Sources/Uses
Herbicidal pre-emergence control of annual weeds; [HSDB]
Comments
Sesone is a gastrointestinal irritant. In animal experiments, it causes liver and kidney injury. [ACGIH] "Overall, it appears that the chlorophenoxy herbicides have led to little or no hepatic injury. Where sufficient occupational exposure seems to have led to hepatic abnormalities (e.g., toxic porphyria), the presumed chemical culprit has been the contaminating TCDD, rather than the herbicide per se." [Zimmerman, p. 415] See "2,4D."
Restricted
The production of Crag herbicide in the United States was discontinued. [ACGIH]
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
Insufficient data
Bioaccumulates
Yes
TLV (ACGIH)
10 mg/m3
PEL (OSHA)
15 mg/m3(total dust), 5 mg/m3(respirable fraction)
IDLH (NIOSH)
500 mg/m3
Excerpts from Documentation for IDLHs
Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for Crag® herbicide. Therefore, the revised IDLH for Crag® herbicide is 500 mg/m3 based on acute oral toxicity data in animals [Carpenter et al. 1961; Gunther 1962; Sine 1991]. This may be a conservative value due to the lack of acute toxicity data for workers.
Vapor Pressure
0.1 mm Hg
Adverse Effects
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
ACGIH Carcinogen
Not Classifiable
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: