Carbadox

Agent Name
Carbadox
CAS Number
6804-07-5
Formula
C11-H10-N4-O4
Major Category
Other Uses
Carbadox formula graphical representation
Synonyms
2-Formylquinoxaline 1,4-dioxide carbomethoxyhydrazone; 3-(2-Chinoxalinylmethylen-1,4-dioxid)methylkarbazat [Czech]; Carbadoxum [INN-Latin]; Fortigro; GS 6244; Getroxel; Hydrazinecarboxylic acid (2-quinoxalinylmethylene)-, methyl ester N(sup 1),N(sup 4)-dioxide; Karbadox [Czech]; Mecadox; Methyl 3-(2-quinoxalinylmethylene)carbazate N(sup 1),N(sup 4)-dioxide; Methyl 3-(2-quinoxalinylmethylene)carbazate-N1,N4-dioxide; [ChemIDplus]
Category
Animal Feed Additives
Description
Yellow solid; Practically insoluble in water; [Merck Index]
Sources/Uses
Used as a veterinary antimicrobial agent and a feed additive for growth promotion of swine; [HSDB] Has been used to treat swine with dysentery, but prohibited in UK after reports of carcinogenicity; [Drug Information Portal]
Comments
May cause photosensitization; [ICSC] Nalidixic acid and ciproflaxacin are similar antibiotics known to cause photosensitivity after ingestion (not occupational). [Marks, p. 203] May induce photoallergic skin reactions in stockmen; Weaned pigs fed 50-100 mg/kg carbadox medicated food for 5-10 weeks had weight loss and histological changes in the adrenal glands; In feeding studies of pregnant rats at doses of 100 mg/kg, caused embryo-lethal and teratogenic effects; [HSDB] May cause irritation; Targets the liver; [MSDSonline]
Biomedical References

Exposure Assessment

Vapor Pressure
6.2E-10 mm Hg

Adverse Effects

Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Dermatotoxin
PACD (photoallergic contact dermatitis)

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: