o-Toluidine

Agent Name
o-Toluidine
CAS Number
95-53-4
Formula
C7-H9-N
Major Category
Nitrogen Compounds
o-Toluidine formula graphical representation
Synonyms
1-Amino-2-methylbenzene; 1-Methyl-2-aminobenzene; 2-Amino-1-methylbenzene; 2-Aminotoluene; 2-Methyl-1-aminobenzene; 2-Methylaniline; 2-Methylbenzamine; 2-Methylbenzenamine; 2-Toluidine; Aniline, 2-methyl-; C.I. 37077; o-Aminotoluene; o-Methylaniline; o-Methylbenzenamine; o-Toluidin [Czech]; o-Toluidine; o-Toluidyna [Polish]; o-Tolylamine; [ChemIDplus] UN1708
Category
Amines, Aromatic
Description
Colorless to pale-yellow liquid with an aromatic, aniline-like odor; [NIOSH]
Sources/Uses
An intermediate used in the organic synthesis of dyes, pharmaceuticals, and other chemicals; [ACGIH]
Comments
Methemoglobinemia, bladder irritation, and hematuria have been reported in exposed workers. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] May cause methemoglobinemia and kidney injury; [ICSC]
Reference Link #1
Biomedical References

Exposure Assessment

BEI
Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]
Skin Designation (ACGIH)
Yes
TLV (ACGIH)
2 ppm
PEL (OSHA)
5 ppm
IDLH (NIOSH)
50 ppm
Excerpts from Documentation for IDLHs
Human data: It has been reported that a 60­minute exposure to 40 ppm produces severe toxic effects [Goldblatt 1955]. It has been reported that 100 ppm is the maximum concentration endurable for 1 hour without serious consequences [Sax 1975].
Vapor Pressure
0.26 mm Hg
Odor Threshold Low
0.02 ppm
Odor Threshold High
6.6 ppm
Lethal Concentration
LC50 (rat) = 862 ppm/4h
Explanatory Notes
Odor threshold from AIHA; Flash point = 185 deg F; VP from HSDB;
NFPA
high ambient temp required

Adverse Effects

Methemoglobinemia
MetHgb is secondary toxic effect
Nephrotoxin
Yes
IARC Carcinogen
Established
NTP Carcinogen
Human carcinogen
ACGIH Carcinogen
Confirmed Animal

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent:

Activities

Activities with risk of exposure: