p-Toluidine

Synonyms

1-Amino-4-methylbenzene; 4-Amino-1-methylbenzene; 4-Aminotoluen [Czech]; 4-Aminotoluene; 4-Methylaniline; 4-Methylbenzenamine; 4-Toluidine; Aniline, p-methyl-; Benzenamine, 4-methyl-; C.I. 37107; C.I. Azoic Coupling Component 107; CI 37107; CI Azoic Coupling Component 107; Naphtol AS-KG; Naphtol AS-KGLL; Toluidine, p-; p-Aminotoluene; p-Methylaniline; p-Methylbenzenamine; p-Toluidin [Czech]; p-Toluidyna [Polish]; p-Tolylamine; [ChemIDplus] UN1993

Category

Amines, Aromatic

Description

White solid with an aromatic odor. [Note: Used as a basis for many dyes.]; [NIOSH]

Sources/Uses

Intermediate used in the organic synthesis of dyes, reagents, and other chemicals; [ACGIH]

Comments

Solid form causes first degree burns on short exposure; [CHRIS] "In the United Kingdom between 1961 and 1980, chloroaniline, p-toluidine, nitrobenzene, and nitrochlorobenzene were the most common industrial causes of methemoglobinemia. Dermal exposure was a more frequent route of toxicity than inhalation with these compounds." [Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988.] Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] May cause methemoglobinemia and kidney injury; A potential skin sensitizer; [ICSC]

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Yes

2 ppm

0.286 mm Hg

0.02 ppm

Odor Threshold High

3.2 ppm

LC50 (rat) > 640 mg/m3/1h

Explanatory Notes

Odor threshold from AIHA; Flash point = 87 deg C; VP from HSDB;

Reference Link #2

high ambient temp required

Yes

MetHgb is secondary toxic effect

Skin burns

Confirmed Animal

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Activities

Activities with risk of exposure:

• Smoking cigarettes